Now That's What I Call Music! 43 was released on August 7, 2012. It is the 43rd edition of the Now! series in the United States. It debuted at number one on the Billboard 200 albums chart with sales of 111,000 copies in its first week of release, becoming the 16th number-one album in the series' franchise.

Now! 43 features two number-one Billboard Hot 100 hits, "Call Me Maybe" and "Part of Me".

Instead of the main version of "Payphone", which featured Wiz Khalifa, the "No-rap" version was included on this album.